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Diary Prequel Package, pp.206-207 · diary_prequel:email:00004
Page text: p.206, p.207 · original PDF
- Date
- 2009-03-16 12:35
- Type
- email · email
Tony -
case is being heard by the UCSF transplant committee on February
21st. Other than
history of PML (diagnosed in early '96, went on potent, high dose
combination ARV therapy, quadruple dose saquinavir (early version, not terribly
bioavailable), 1200 mg AZT, double dose 3TC and something else, I can't remember -
PML went into remission and has remained in remission since then. His CD4+ cell count
never dropped below 400) he is eligible for transplantation. He responded well to RFA
(they say his lesions, 'disappeared'), but I understand that there might be growth of a new
lesion. But again, from my understanding, he's still eligible for transplantation (other
than the prior history of PML) and has a MELD score of 17.
At any rate, I think the issues before the transplant committee are a few .. 1) protocol
exception (for the HIV transplant project), 2) off protocol transplant and 3) do they want
to potentially "waste" a liver on someone who could, theoretically, have rapid PML
progression and die shortly after transplantation. The case of PML progression following
transplantation that I'm aware of was in a person without a prior history of PML.. why
this person developed PML and progressed when nearly everyone has the JC virus is
unknown, of course.
PML has been resolved for 10+ years. I know arguing that
last point is the challenge, but any way(s) that you could weigh in on this would be
valued greatly. Let me know if you have ideas.
Thank you!
-Brenda
Mar. 14 - April 7, 2009 - Incredible activity in the Administration in trying to revitalize
the economy with bailouts and takeovers of companies such as GM, AIG, etc. Stack
Market still volatile, but seems to have settled between 7000 and 8000 down from 14,000
in Oct. 2007.