Diary Prequel Package — page 207

(they say his lesions, 'disappeared'), but I understand that there might be growth of a new lesion. But again, from my understanding, he's still eligible for transplantation (other than the prior history of PML) and has a MELD score of 17. At any rate, I think the issues before the transplant committee are a few .. 1) protocol exception (for the HIV transplant project), 2) off protocol transplant and 3) do they want to potentially "waste" a liver on someone who could, theoretically, have rapid PML progression and die shortly after transplantation. The case of PML progression following transplantation that I'm aware of was in a person without a prior history of PML.. why this person developed PML and progressed when nearly everyone has the JC virus is unknown, of course. PML has been resolved for 10+ years. I know arguing that last point is the challenge, but any way(s) that you could weigh in on this would be valued greatly. Let me know if you have ideas. Thank you! -Brenda Mar. 14 - April 7, 2009 - Incredible activity in the Administration in trying to revitalize the economy with bailouts and takeovers of companies such as GM, AIG, etc. Stack Market still volatile, but seems to have settled between 7000 and 8000 down from 14,000 in Oct. 2007. Mar. 8, 2009 - Had my first entry into interactions with the new Administration. Background is that there have been recent reports of the terrible situation in Washington, D.C. regarding prevalence of HIV/AIDS with 3% of the population infected and 6.5% of black men. This is worse than 22 countries in sub-Saharan Africa. We at NIAID and NIH (Fauci, Dieffenbach, and Henry Masur) have been putting together a collaborative program with DC Department of Health (Shannon Hader) to address this issue with a combined research-care program that also involves the recently promoted "test and treat" concept. This model (appeared in Lancet on Nov. 27, 2008) suggests that if you test everyone 1X per year and treat people immediately regardless of their CD4+ T cell count or viral load, you could decrease the level of virus in the community so that you could conceivably get the Ro to <1, which would in essence shut off the AIDS epidemic. Such a concept would require the answering of questions of safety, efficacy, adherence, access to people for testing, benefit to individual versus community, cost effectiveness, etc. We could help to district by making this "test and treat" research agenda a part of our collaborative effort with the District. While this is going on, Zeke Emanuel is now detailed to OMB as an assistant to OMB Director Peter Orzag to handle health related issues. Zeke heard about the initiative and feels that it would be a good idea to get the WH and the POTUS involved in an announcement of such a program for the District. Thus, I was called down to the OMB in Room 263 in EEOB to present the program. Zeke was present as was Jeff Crowley, the new WH AIDS Coordinator and Director of the Office of National AIDS Policy. Connected by phone was Jenny Backus (HHS Public