A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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No. Yeah, so that was first published in 2013 as a sequence fragment, that I didn't notice. And then they came out with a sequence, I think, in, what, 2017, 2018, somewhere around there. It did not catch my notice. I mean, oftentimes, every once in a while we do searches on sequences, to see if there's anything interesting out there that we might want to work on. But it didn't catch our attention. So it didn't come to my attention fully until they published their paper in January of 2020. And so I agree with people like Elaine Chen and others that have looked at the sequence information around that virus and say that I don't know. Like she has reported, we could not recreate the full-length sequence that they provided, based on the sequence information that they provided. There were gaps, in other words. It was not complete. Some of it was very good, where they had good coverage, so they had a lot of coverage of that particular chromosome and then they cloned out a specific plasma DNA of that region and sequenced it. So there are regions that DC.Scheduling@LexitasLegal.com are really good and the spike is really good. Polymerase has gaps in it. We can't close those gaps based on their sequence, using all kinds of different program to try to do it. Now, they may have an in-house program that they used, but personally I think they used a reference sequence and they guessed, to fill the gaps. That's my gut feeling.
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And I had asked you if you had ever not published something. So that's part of what happened in this case. I understand it was partially uploaded and then it was under embargo. So have you ever had a sequence or something under embargo that then you withdrew? I just want to make sure that my initial question of you didn't publish anything is complete, because I understand that you can submit something.
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You can pull it off, yeah. I don't believe we have ever, no. I mean, why would we? We were using public sequences to build viruses. It's not like we were doing this de novo.
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Okay.
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2026-04-10 09:00
Ralph S. Baric
Just to let you know, we have ordered a molecular clone for RaTG13. That genome is heavily debilitated. We eventually isolated it. We have not finished submitting the paper.
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Okay. And when did you isolate it? DC.Scheduling@LexitasLegal.com
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Maybe two and a half years ago.
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Okay. Do you think that Dr. Shi and WIV had the technical capability of doing the work proposed in DEFUSE on their own?
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With WIV1, absolutely.