Private channel session 1415
50 messages over 2h 13m, 2021-05-21 – 2021-05-21.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
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https://www.sciencedirect.com/science/article/pii/S0042682219303022?via%3Dihub
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https://pubmed.ncbi.nlm.nih.gov/27999425/
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https://pubmed.ncbi.nlm.nih.gov/27535067/
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Easy enough to find the research links between WIV, the wildlife rescue and Yang Guoxiang. Looks solid. Avian flu and lions! @Kristian Andersen we might use that last reference in an upcoming application.
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Completely made up, top to bottom. Tell me this isn't 2003 all over again - WMD this time being WIV (see the resemblance.... :thinking_face:). Total crazy town. https://republicans-intelligence.house.gov/uploadedfiles/covid-19_and_the_wuhan_institute_of_virology_19_may_2 021.pdf
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As Uncle Joe Biden might say this is a BFD! Here, we report the genome characterization and viral receptor analysis of a novel lineage of SARSr-CoVs in Tongguan town, Mojiang county, Yunnan province in China in 2015, the same location where we found bat RaTG13 in 2013 [1].
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BFD. Let's hope it's published before the war starts.
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Very interesting - I love how they totally do not drop a beat. Interesting viruses - maybe pangolins after all? I'm glad they gave Jesse his eight mysterious viruses. Turns out they weren't SARS-CoV-2 :man-shrugging: (ANY idiot would realize this if not so deep into crazy land)
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Hybrid pangolin / mink / whatever farming happening in China? Hubei?
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Don't rule out those pangolins! Zheng-Li Shi has nerves of steel....
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Devin Nunes - - I love the tweets from his mom and his cow.
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Very much looking forward to hearing what the Bloomshitters and the Parasites will say about this....
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@Kristian Andersen Totally fucking mental. 2003 again as you say.
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They're going to go fucking crazy. I swear - the conspiracy theories on my Twitter timeline right now are off the chart.Total craziness.
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Yup. It's going to be great.
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Shi's viruses - Eddie where's RmYN05 and those guys from? [shared file(s): Screen Shot 2021-05-21 at 4.33.12 PM.png]
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Rs7896 is the new one - clade sticking out near the bottom
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~98% identity to those RmYN05-like viruses. Interesting.
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YN = Yunnan
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Rm = Rhinolophus malayanus
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How does the ORF1ab tree look? I usually think that is more informative. The RpYN06 paper has just been accepted in Cell.
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shared file(s): 2021.05.21_nucleotide_genome RAxML Tree.nex, 2021.05.21_nucleotide_genome RAxML Tree.nex.pdf
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I have a sim plot - lemme share
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ORF1ab similar. Let me make a tree [shared file(s): simplot.pdf]
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(similar to the Rm ones)
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Black line is the new one
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@Kristian Andersen What's this tree? Complete genomes?
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@Kristian Andersen Yeah
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@Kristian Andersen Here's a nicely formatted/annotated alignment [shared file(s): 2021.05.21_nucleotide_genome.geneious]
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Thanks!
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Sorry - it is too late for simplots and recombination. Will take a look tomorrow
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No kidding. Good night!
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(I shared the full alignment in the thread - so you have that for tomorrow. All CDS annotated)
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Hope the bioRxiv post goes up soon :bomb:
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COME ON ALREADY!!
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Post the good tweets here for reading over coffee...
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N/A
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Spike and ORF1ab trees - note these are midpoint rooted, because I have no idea how to root these guys. [shared file(s): 2021.05.21_nucleotide_Spike RAxML Tree.nex.pdf, 2021.05.21_nucleotide_Spike RAxML Tree.nex, 2021.05.21_nucleotide_ORF1ab RAxML Tree.nex.pdf, 2021.05.21_nucleotide_ORF1ab RAxML Tree.nex]
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Paper is online - https://www.biorxiv.org/content/10.1101/2021.05.21.445091v1
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Let the show begin...
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Eddie, the lab leak theory isn't a conspiracy theory, you know? Just so that's clear...
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Sorry, I keep forgetting...
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I know. It's easy to forget. Separately - fucking hell, these viruses - SO MUCH DIVERSITY!!!!!!!!!!
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Indeed. Doesn't take much to think that any particular RBD+FCS combination could arise. Nature does it again.
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Nah. I had bookmarked that BioProject previously so I just came across it.
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Ah yes, I remember now.
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But yeah - I _could_ have waited ten minutes... Others found the paper before me though
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Jonathan Eisen is a stand-up guy on this.
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He is. He's able to keep a cool head.
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WIV are in an impossible position: don't release the data and they are accused of hiding it, release it and they are accused of faking it. Having no PCR/antibody positives at the WIV and they are accused of lying, having n = 1 caseat WIV then that would be patient zero.