Slack / Private Message Drop — page 790

[2021-05-12 18:53:42] [Kristian Andersen] Haha, true. [2021-05-12 21:27:51] [Eddie Holmes] eDim must be one of the most obnoxious people on the planet. [2021-05-12 21:29:16] [Kristian Andersen] :100: [2021-05-12 21:29:29] [Kristian Andersen] I really hope there isn't a Ms. eDim. Imagine that. [2021-05-12 21:32:29] [Eddie Holmes] I'd rather be a raccoon dog in a wet market [2021-05-12 23:09:08] [Kristian Andersen] Oh, David got specific - let's crush their arguments... [2021-05-12 23:13:36] [Eddie Holmes] I don't think you an even call those arguments. I've got no stomach for a long email fight. I think we can say just say we considered all those points in January 2020 but then decided to do some science. [2021-05-12 23:15:20] [Kristian Andersen] • First cases connected to market • Triangulation of early cases and deaths • Virus found at the market - https://twitter.com/K_G_Andersen/status/1377462189632614404?s=20 • Two different lineages circulating early - https://virological.org/t/early-appearance-of-two-distinct-genomic-lineages -of-sars-[...]ldlife-markets-suggests-sars-cov-2-has-a-natural-origin/691/1 • Links back to wildlife farming in e.g., Yunnan • Some evidence of wild animals at market • Very convoluted route from cave > lab > researcher > market (and hugely unlikely somebody would magically find the next pandemic virus) • Andrews equations above - love some good math • No evidence of genetic markers one might expect from lab experiments (they _always_ use the same reagents/methods) • Would require conspiracy • Highly similar viruses found in multiple species in multiple places • ACE2 + FCS combo (all found in nature) > super-charged for emergence • Sero prevalence studies showing very frequent encounters • Long evolutionary gap to Yunnan bats • Yunnan bats look close because they mainly sampled Yunnan bats • No reason not a publish a closer virus before the pandemic • "Closest known (not that close) viral relatives in nature are ~1000 miles from Wuhan" - So the known relatives are not the close relatives and thus the fact they are far away is expected • Virus is adapted to spread in multiple hosts (e.g. mink). • Same RBD found in pangolins so it is nature • FCS also 100% a natural feature: https://twitter.com/K_G_Andersen/status/1391507230848032772?s=20 • Serology survey from WIV shows no exposure • WIV, authorities, Zhengli, and other scientists denied having done any work on the virus prior to the outbreak • Zoonotic origin has a huge advantage in its favor in that it naturally selects for human transmissible viruses - the