Slack / Private Message Drop — page 466

https://www.acpjournals.org/doi/full/10.7326/M20-6519 Surprise, surprise - NO prophylactic effect of HCQ for SC2 acquisition in contacts. It did make some ppl sick thou. [2021-01-30 15:08:43] [Eddie Holmes] Petrovsky should stick to failing to make vaccines. [2021-01-30 15:09:40] [Eddie Holmes] [thread - ID: 2021-01-30 05:40:40] @Robert Garry Great spot Bob! [2021-01-30 15:14:40] [Robert Garry] [thread - ID: 2021-01-30 05:40:40] @Robert Garry Yet another mutation involving aromatics. Prof Bill looking closely at that aspect. The spike domains are literally glued together with pi:pi interactions. [2021-01-30 15:15:24] [Eddie Holmes] [thread - ID: 2021-01-30 05:40:40] @Robert Garry Really interesting [2021-01-31 08:55:27] [Kristian Andersen] Yikes. [shared file(s): EtD6MChXMAECBlF.jpeg] [2021-01-31 08:58:08] [Kristian Andersen] While we obviously can't conclude anything based on this curve, based on some of the information I'm getting on P.1 and seeing this, I'm pretty worried the IFRs of all these lineages are also increased. Not good. [2021-01-31 09:04:48] [Andrew Rambaut] Again - really difficult to separate IFRs from where these lineages are and how stretched the care is. [2021-01-31 11:33:13] [Robert Garry] Anyone know where the ZA cases are clustering - when SC2 hit NOLa hard it was the African-American communities overwhelmingly - more predisposing conditions. [2021-01-31 14:01:54] [Robert Garry] Just sent a google drive invite - https://docs.google.com/document/d/17-2hi7-fNsjE44himeCkm1PoZ7_-ncvpxUlhShZzDCU/edit Please send feedback - would be great if all could join but understand any declines or hesitancy. Nothing in stone, including the "tone." There's some decent science hidden there. [2021-01-31 14:17:00] [Eddie Holmes] Brill, thanks Bob!! I'll get onto it. [2021-01-31 14:48:35] [Kristian Andersen]