Slack / Private Message Drop — page 442

@Andrew Rambaut Agree with this - optimal cleavage might vary depending on multiple factors - cleave in the wrong tissue or wrong time not good. - An optimal cleavage site is RRXRR. Not all X's equal so RRRRR among the best. [2021-01-23 14:52:01] [Eddie Holmes] But I can of course use them if necessary. [2021-01-23 14:53:21] [Andrew Rambaut] True - would be interesting if some of that got out (doesn't look good for CCDC) [2021-01-23 14:54:18] [Eddie Holmes] Oh no. [2021-01-23 14:57:12] [Robert Garry] Wow. [2021-01-23 14:58:25] [Robert Garry] "Also, do you/we plan to write-up these Virological posts into a paper?" yes - needed! on it. [2021-01-23 15:05:30] [Kristian Andersen] Whoa Eddie - that's pretty scary language in that email. [2021-01-23 15:28:24] [Eddie Holmes] Yes, very bad. You know, all the bad stuff that came out of this, all the attacks that are ongoing, are due to George Gao. No doubt. [2021-01-23 15:28:56] [Eddie Holmes] Thanks for working on the paper Bob! [2021-01-23 16:50:55] [Andrew Rambaut] spike L18F is seen in 310 genomes within B.1.1.7 in the UK - more convergence [2021-01-23 17:08:16] [Kristian Andersen] For fuck sake! This is adding immune escape to the increased transmission. Just need to add E484K and L417N/T and we're good to go. [2021-01-23 17:12:33] [Andrew Rambaut] Here is a full list of variants in B.1.1.7 on sites with mutation seen in P.1 and B.1.351 (and not originally in B.1.1.7): ```Gene Mutation Original lineage Seen in B.1.1.7 ORF1ab S1188L P.1 A/L/P 1/4/2 genomes K1655N B.1.351 M/N 1/3 genomes E5665D P.1 D 2 genomes spike L18F P.1/B.1.351 L 310 genomes T20I P.1 N 17 genomes P26S P.1 H/L/S 1/2/5 genomes