Slack / Private Message Drop — page 332

Knocking out two neutralizing epitope would not likely be a good thing for vaccine efficacy. Agree about Oxford/AZN - just begging for escape. [2020-12-20 19:47:26] [Kristian Andersen] I really hope it isn't that easy... We'll know soon enough. Massive-scale epitope mapping really needed. [2020-12-21 04:49:58] [Robert Garry] Indeed - like hiv, ebov and lasv gps cov spike has an impressive glycan shield (>20 per monomer). The chinks (ie. epitopes) are not going to be numerous. [2020-12-21 05:04:02] [Robert Garry] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818208/ So, here's a look at the possibilities for a strong interaction of ACE2 Y41 and the Y of N501Y via aromatic stacking. [2020-12-21 08:41:27] [Robert Garry] Preaching to the choir, but need to get away from treating with single monoclonals or combinations that target the same domain. [2020-12-21 10:03:54] [Kristian Andersen] @Andrew Rambaut - thanks for taking down the post from Nigeria. I flagged it immediately this morning too with the team, so they need to get this updated and correct - Paul is working on it. [2020-12-21 10:57:54] [Andrew Rambaut] I made it a private message. [2020-12-21 11:05:40] [Kristian Andersen] He's working on a new version - need to get the basics right... [2020-12-21 11:08:17] [Andrew Rambaut] Do you know if pangolin assigned it B.1.1.7 or if it was just the presence the mutation that suggested it to them? We are putting a special bit for pangolin to require 3 of the mutations and no wildtype at these sites to make sure there are no mis-classifcations. To risky otherwise. [2020-12-21 11:15:26] [Kristian Andersen] I can't quite figure out if pangolin actually assigned it to that lineage - the question was asked earlier, but no reply yet [2020-12-21 11:21:59] [Andrew Rambaut] It didn't - or rather the latest version doesn't. [2020-12-21 11:25:34] [Kristian Andersen] OK, thought so. Not really sure what he did... [2020-12-21 13:06:09]