Slack / Private Message Drop — page 273

Perhaps we should ask Nature Medicine if they up for Proximal Origins II? Given that the 1st one has 5 million accesses they might be up for it. I'll just add notes your doc Andrew. [2020-11-21 14:55:01] [Eddie Holmes] I think we can lance the butt lesion for the new version though. [2020-11-21 14:55:55] [Andrew Rambaut] Definitely no BL this time. [2020-11-22 09:22:28] [Robert Garry] Virological post is submitted - thanks all! [2020-11-22 09:39:05] [Kristian Andersen] This is a great post - thanks Bob. Now, let's see how the alignment trolls of yesterday will interpret this one... ("it's just a simple BLAST search, right?"). [2020-11-22 10:03:10] [Kristian Andersen] I think we really need to start making _less_ user-friendly software... Here's one of the alignment trolls from yesterday showing that the RmYN02 paper is definitely wrong. Obviously. The issue is - this kind of uninformed (this guy's an MBA) analyses actually manages to get traction and for this one in particular, even a published paper. [shared file(s): Screen Shot 2020-11-22 at 10.00.18 AM.png] [2020-11-22 10:52:49] [Kristian Andersen] And just to Proximal v2.0 - I'm also keeping a few notes here: https://andersen-lab.com/secrets/data/sars-cov-2-origins/ [2020-11-22 12:04:28] [Eddie Holmes] Yes, brilliant job Bob and Kristian! Made my day. [2020-11-22 12:05:21] [Eddie Holmes] Let's hope that sales of tinfoil take a hit. [2020-11-22 12:19:55] [Robert Garry] THANKS - means a lot! [2020-11-22 13:11:23] [Kristian Andersen] One point I added to Bob's great post - that I'm not sure has been mentioned previously - a SARS-like CoV that is able to cause a human pandemic _is much more likely_ to have a FCS than a non-pandemic SARS-like CoV. https://virological.org/t/naturally-occurring-indels-in-multiple-coronavirus-spikes/560/2 [2020-11-22 13:14:27] [Kristian Andersen] And I don't know - but I find myself to be particularly witty here: https://twitter.com/K_G_Andersen/status/1330617703808135168?s=20.