Slack / Private Message Drop — page 266

[2020-11-19 12:58:46] [Robert Garry] Agree - pretty lost - Should point out that the Ebola reservoir is unknown and new reservoirs of Lassa virus still being uncovered. Point taken about HIV - there's quite a gap. The transmission on seafood seems like a fluke to me. [2020-11-19 13:00:21] [Robert Garry] Here's a figure compiling indels at the S1/S2 ans S2' spike junctions of coronaviruses. Indels are the rule not the exception. Yes- virological post.... [shared file(s): image.png] [2020-11-19 13:07:15] [Robert Garry] The pesky predicted O-linked glycan sites, which are otherwise rare [a few notable exceptions], keep popping up at the spike s1/s2 and s2' junctions. [2020-11-19 13:13:03] [Eddie Holmes] Love that figure Bob. Brilliant. [2020-11-19 14:45:48] [Andrew Rambaut] HIV-1 has clear links with Chimps with recombinations that essentially prove the last jump was chimps to humans (and HIV-2 from sooty mangabeys - absolutely clear) [2020-11-19 14:49:45] [Andrew Rambaut] It sounds like ramblings at the end of a long night in a pub. That would be nice. [2020-11-19 14:56:09] [Robert Garry] Oh yeah - I believe the chimp link but of course it's definitely complicated - could be like one of the possible SARS-CoV-2 scenarios - a lot of undetected circulation. And yes I forgot - HIV-2 is indeed a sooty virus! Looking forward to the pub for sure! [2020-11-19 15:01:18] [Andrew Rambaut] There certainly was undetected human circulation of course (about 60-70 years). It is just an odd example to try to compare SC2 to. [2020-11-19 15:20:04] [Robert Garry] Agreed and where did "is HIV really from a monkey?"come from? [2020-11-19 15:24:46] [Andrew Rambaut] I think he is trying to be profound. Or he is being forced to say it to deflect people from the truth. [2020-11-19 15:50:51] [Eddie Holmes] I think it's an attempting to be profound but instead is rambling. That's a George signature. [2020-11-19 21:30:00] [Kristian Andersen] https://www.nytimes.com/2020/11/20/business/media/covid-misinformation-china.html?action=click&module=T op%20Stories&pgtype=Homepage