Chairman Paul Letter to DNI Gabbard — page 14
of 56 pages · text recovered by OCR
← p.13 p.15 → · this page in the original PDF · package
Drivers of CoV Evolution
e CoV Genome Size: 32Kb
esa Remneae
e CoV Mutation Rate
oi
a 10°
Regulated Fidelity { » /
--_--_---->>
}
(nsp14: ExoN)
\
/
» Environmental Change
Fidelity rates change
Ga,
:
a
nea
e High Rates RNA Recombination
G7
m 25% during mixed infections
= Modular evolution
@ Plastic Surface Glycoprotein
m Tolerates high rates of mutation
m Deletions and Insertions (tropism, antigenicity)
m Recombination (modular evolution)
Position Piece: CoV: An RNA Proofreading Machine Regulates Replication and Fidelity (RNA Biol, 2011}; Dudas G. Viru
Eckerle et al., Plos Pathogens 2010; Graham et al., Nature Medicine 2012; Smith et al., Plos Path 2014; Kirchdoefer et a
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Records on this page
| Record | Date | Type | Pages |
|---|---|---|---|
| letter_dni:exh:00005 | — | attachment | 14 |
| B Group Next Week | 2020-01-23 | 7–14 |