Chairman Paul Letter to DNI Gabbard — page 13
of 56 pages · text recovered by OCR
← p.12 p.14 → · this page in the original PDF · package
Drivers of CoV Evolution
@ CoV Genome Size: 32Kb
__, CoV Replicas
@ CoV Mutation Rate
I ea
a 10°
--> Regulated Fidelity g
(nsp14: ExoN)
u Environmental Change
@ Fidelity rates change
Cnn
é
:
.
ee
e High Rates RNA Recombination
=< ~
m 25% during mixed infections
Repleatve re
mw Modular evolution
cS)Bc
Position Piece: CoV: An RNA Proofreading Machine Regulates Replication and Fidelity (RNA Biol. 2011), Du
Eckerle et al., Plos Pathogens 2010; Graham et al., Nature Medicine 2012; Smith et al., Plos Path 2014
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Records on this page
| Record | Date | Type | Pages |
|---|---|---|---|
| B Group Next Week | 2020-01-23 | 7–14 |