Gates Package — page 30

First NHP Study Results - Preliminary Two arm, vehicle controlled study administering favipiravir once a day by oral gavage Favipiravir 400 mg/kg/d once followed by 200mg/kg/d for 13 days Animals sedated once a day to protect technician EBOV challenge four days after beginning favipiravir Control monkeys died within the expected timeframe One test animal survived to Day 28, the others lived longer than controls Viral titers suggested antiviral effect Suggestion of GI abnormalities Histology, PK pending Audit of study pending Confidential