Gates Package — page 1372
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COARPA) Technical Approach- University of California Davis (UCD)
Developing animal species-specific cytomegalovirus (CMV)-based transmissible vaccines
for Lassa virus (LASV) and Ebola virus (EBOV)
Three Interwoven Strands
Virus Ecology
Modelling
Vaccine Development
+
What animal species serve as
*
When and where is the highest
*
Can the vaccine vector be isolated
the major reservoir host?
risk for spillover?
from reservoir animals?
+
What CMY and pathogen virus
+
When is it optimal to introduce
+
Can the vaccine have a limiting halflineages are co-circulating
in
transmissible vaccine, and at what
life "i.e, off-switch" to control
these reservoir hosts?
dose?
environmental dissemination?
+
What is the incidence and
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When are animals most
+
Doss the vaccine prevent infection
prevalence of pathogen in these
susceptible to vaccine
and shedding virus?
animals?
intervention?
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Records on this page
| Record | Date | Type | Pages |
|---|---|---|---|
| gates:exh:00644 | — | attachment | 1372 |