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COARPA) Technical Approach- University of California Davis (UCD) Developing animal species-specific cytomegalovirus (CMV)-based transmissible vaccines for Lassa virus (LASV) and Ebola virus (EBOV) Three Interwoven Strands Virus Ecology Modelling Vaccine Development + What animal species serve as * When and where is the highest * Can the vaccine vector be isolated the major reservoir host? risk for spillover? from reservoir animals? + What CMY and pathogen virus + When is it optimal to introduce + Can the vaccine have a limiting halflineages are co-circulating in transmissible vaccine, and at what life "i.e, off-switch" to control these reservoir hosts? dose? environmental dissemination? + What is the incidence and + When are animals most + Doss the vaccine prevent infection prevalence of pathogen in these susceptible to vaccine and shedding virus? animals? intervention?