Gates Package — page 1333
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© Preliminary
ENGINEER B CELLS
WHAT DOES ENGINEERING B-CELLS INCLUDE?
i
Hematopoietic
Long-Lived
.
.
" Stem Cell
Stem Cell
B-cell
Boel
Universality
cg aa
-=--
)
PNCGRan
In
aX
eh
Genetically
_
y
(
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}
I Ail
introduce
\
Que
CH
WUy
protective
antibody
Add I Delete
gene I gene
BOSH Inne
Continuous
Dose of 4M
recognition
Ab production
B-cells
with
to achieve
decades
protective levels
long
of Ab (10
life-span
ug/ml)
KEY QUESTION(S)
How can we use stem cell engineering to
Know the qualities necessary for differentiation
produce long-lived B-cells?
and delivery of B-cells
WHAT POTENTIAL RELATIONSHIPS
COULD ACCELERATE THIS WORK?
TABBY Gwe BSTEMCELL
") Scripps Research
A &
EMORY
Sina
UNIVERSITY
ARIZONA.
Hostal
And more,
including new
companies
POSSIBLE APPLICATION(S)
S Designer B cells delivered by injection
Not for distribution| 5
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Records on this page
| Record | Date | Type | Pages |
|---|---|---|---|
| gates:exh:00620 | — | attachment | 1333 |