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© Preliminary ENGINEER B CELLS WHAT DOES ENGINEERING B-CELLS INCLUDE? i Hematopoietic Long-Lived . . " Stem Cell Stem Cell B-cell Boel Universality cg aa -=-- ) PNCGRan In aX eh Genetically _ y ( \\ iy } I Ail introduce \ Que CH WUy protective antibody Add I Delete gene I gene BOSH Inne Continuous Dose of 4M recognition Ab production B-cells with to achieve decades protective levels long of Ab (10 life-span ug/ml) KEY QUESTION(S) How can we use stem cell engineering to Know the qualities necessary for differentiation produce long-lived B-cells? and delivery of B-cells WHAT POTENTIAL RELATIONSHIPS COULD ACCELERATE THIS WORK? TABBY Gwe BSTEMCELL ") Scripps Research A & EMORY Sina UNIVERSITY ARIZONA. Hostal And more, including new companies POSSIBLE APPLICATION(S) S Designer B cells delivered by injection Not for distribution| 5