Gates Package — page 1295

TBRU Summary September 20, 2018 Below you will find a compiled summary of the information provided by the 4 TBRU centers. Here are the original files: Center Name PIs Grant Number Accomplishment File Expires ASTRa Henry Blumberg Joel Ernst AI111211 2018 TBRU Annual Meeting_Pre7/31/2021 CLEAR-TB Jerry Ellner David Alland Padmini Salgame AI111276 2018 TBRU Updates and 7/31/2021 LIMAA Branch Moody Megan Murray AI111224 TBRU LIMAA 2018 PI survey.docx 01/31/2022 Tri-I Carl Nathan Mike Glickman AI111143 2018 Tri- I TBRU Updates and 6/30/2021 • TBRUs were awarded in 2014 and run until 2021 (LIMAA continues until Feb 2022) • Total value over 7 years: ~$105M (~$15M/year for 7 years) • Annual cross-collaborative supplement program supports cross-collaborative projects, many led by early career investigators (Projects are ~$200K each/year/center) High-Level Data as of 9/17/2018. Grant years completed: 4; Grant years remaining: 3 • Number of Publications = 144 I. there may be redundant publications in the list if the same publication was listed under two centers II. this number includes both reviews as well as research publications • Number of Trainees = 87 o Number of trainees seeking TB-related independent careers = 33 I. Defined: new faculty position, on the job market, late post-docs • Number of Spin-Off Grants FUDNED = 43 o Number of funded spin-off grants for NI/ESI = 18 o Number of grants waiting review or funding decision: 7 o Funders of spin-off grants: NIH, DoD, Gates, Foundations, etc. • Number of projects in translational categories for all 4 centers o Vaccines: 7 o Drugs: 15 o Diagnostics: 5 o Animal Models: 7 I. These numbers aren't reflective of the full spectrum of work being conducted by the TBRU Network, just an overview summary II. While the TBRU Network has a focus on Paucibacillary disease, there are a number of projects in the translational space