Tony's Diary Package — page 501

1. The summer surge post Memorial day-- USA baseline cases were at 25K day now >L60K/day, inpatients were <30K and now =90K -- we are ina very dangerous place fora further resurgence 2, The virus continues te accelerate faster than our response and this requires an even further accelerated and comprehensive Federal response with aggressive support te States to include strang statements that Europe and States with strong mitigation are impraying-- thereisa clear roadmap tecontainthis virus and preserve the health system: * Continued aggressive communication at the WH level masking requirements at all times outside of immediate household, physically distancing, hand hygiene AND critically limiting of social interactions to the immediate household for the next 60 days while we bridge to the rapid vaccination of the vulnerable populations decreasing hospitalizations and fatalities : thisis a short term sacrifice to protect the vulnerable, We must directly confront the myths that many Americans believe Americans believe that masks don't work, that the epidemic is a hoax, that the figure of !1% of those who died had camorbidities meant that they died trom something else and we have inflated the tatalities --instead af understanding that the co-morbidities predisposed them to severe COVID and deaths have been underreported Clear recommendations to States about the Importance of short term mitigation Interventlons ; restricting indoordining and limiting and/or closing areas of congregation without mask (bars, gyms ebc.) this was successful in the USA in the summer and was successfulin Europe during their tall surge - states across the country are not mitigating adequately to preserve the health System Continued critical guidance an the Holiday season to limitindoorunmasking across households it they choose to gather Aggressive re-allgnment of Ag testing towards tinding and preventing unrelenting silent spread that continues to trigger community spread in waves = a hand full of states are moving in this direction Expansionaf WAT testing now to ensure colleges and K-12 teachers can access routine regulartesting inJanuary Expanding frequency of LTC testing and aligning early vaccination Inte LICE With Medera's potential of one shot resulting In some protectbon - aggressive innnunization of the vulnerable and the elderly could dramatically change hospitalization rates and fatalities In the mext 30-35 days Ensuring rapid tiering of those most vulnerable to rapldvaccine Inmunization access Immediately uponEWaA--this may require implementationsupport to the states and full utilization of federal qualified health clinics Date Milestone Dec 1 Covid-19 illness documented (unpublicized Nov 17*) Jan 10 SARS-CoV-2 virus sequenced Jan 15 NIH designs mRNA vaccine in collaboration with Moderna Mar 16 Moderna Phase 112 trial begins May 2 Pfizer/BioNTech Phase 112 trial begins July 14 Moderna Phase 112 trial published in NEJM July 27, 28 Moderna and Pfizer/BioNTech Phase 3 trial begins Aug 12 Pfizer/BioNTech Phase 112 published in Nature October 22,27. Enrollment in both Phase 3 trials complete; >74,000 participants Nov 9 Pfizer/BioNTech announces interim analysis efficacy > 90% Nov 16 Moderna announces interim analysis efficacy 94.5% Nov 18 Pfizer/BioNTech announces 95% efficacy as final result Nov 20 1st EUA submitted by Pfizer/BioNTech Nov 27 Distribution of vaccine by UAL charter flights throughout US Dec 10 FDA External review of Pfizer/BioNTech EUA Dec 11 Phase 1a Vaccination begins for health care professionals* *Provisional on positive external review Photos below of Fauci making rounds with Clinical Center inpatient and Clinic Staff - from October 2020