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record in countermeasure programs demonstrates quite clearly, however, ignoring market realities makes a difficult process even more challenging. The easiest way to enlist the aid of market forces is by developing specific countermeasures that have legitimate markets. Such was the case with our pandemic influenza program that successfully engaged several pharmaceutical companies and that resulted ultimately in a safe and highly effective vaccine. [The success of our pandemic influenza program illustrates this principle in a dramatic way. In other cases, the solution has been to focus on "multi-use" products that address many threats simultaneously or that among a wider range of indications demonstrate efficacy against specified threats. Where therapeutics and diagnostics are concerned, leveraging market 'Commented [a2]: Tlnow that Thave read this many times and have not changed it. However, it ust stuck me thatthe use ofthe pandemic influenza program asa "succes" story might decrease our {redbiity since the USG pot am "F"for this and this has embarassed the POTUS. Thus, Ihave changed the wording somewhat afmuci 2010-02-11 20:10:00