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March 13, 2022 12:04 AM EST To: jbloom fredhutch.org> CC: zishi wh.iov.cn>; huben ecohealthalliance.org> Subject: Re: RaTG13 sequence? wh.iov.cn>; Hongying Li <@ecohealthalliance.org>; Peter Daszak Regarding the receptor, I also want to emphasize that there should be at least one more unknown receptor (let's say X) responsible for Sarbecovirus transmission in bats, particularly for the majority that don't use ACE2. So, let's move our focus out of ACE2, but take an evolutionary point of view: is ACE2-usage the trend of evolution or not-usage the direction? Then you may understand that RaTG13 may just lie in the boundary of the two directions. -- BIZARRE -- BAEK Bloom PhD, Jesse Do tredhutch.org> AWA 20224703138 11:44 weeEA ENN <llwh.iov.cn> Pik @wh.iov.cn>, /ji8<pMI@wh.iov.cn>, 4)4,3z<li@ecohealthalliance.org>, Peter Daszak{@ ecohealthalliance.org> Sassi Re: Re: Re: RaTG13 sequence? Since we're on this interesting thread, can I ask one more question? Is it known how sarbecoviruses naturally transmit in bats? Is it fecal oral or respiratory or unknown? Jesse Bloom Professor, Fred Hutchinson Cancer Research Center Investigator, Howard Hughes Medical Institute