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Gates Package, p.847 · gates:exh:00287
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- Vaccines
Fig.6. -globin analysis after ex vivo base editing with by HDAd-EF1a.ABE8e. A)
Percentage of -globin positive peripheral RBCs measured by flow cytometry at different
time points after transplantation. N=5 animals.
B) qRT-PCR for globin mRNA (human
HBG/-globin vs mouse HBA/a-globin; human HBG/-globin vs mouse HBB/-globin;
human HBG/-globin vs human HBB/-globin). Shown are the fold changes between
untreated and treated animals. N=5 animals. C) Percentage of human −globin chains
relative to mouse a−globin chains, mouse −globin, and human -globin chain measured
by HPLC.