COVID-19 Records

Low Dose Moderna

Gates Package, pp.1198-1200 · gates:email:00781

Page text: p.1198, p.1199, p.1200 · original PDF

Date
2021-07-26 15:23
Type
email · email
cc
Robert Nabors
sender
Trevor Mundel
to
Bill Gates, Anthony S. Fauci
Topics
VaccinesGates Foundation involvementTherapeutics and treatments
https://www.medrxiv.org/content/10.1101/2021.06.30.21259787v1.full.pdf Bill, Tony, this is the low (1/4) dose Moderna data which looks quite strong - I know Sette has a lot of additional data he presented over the weekend and I'm trying to get this from him. Regulatory authorities (EMA and MHRA thus far) have agreed to immunogenicity phase 3 trials for the new vaccines coming along due to the inability to do standard phase 3 - in the 2 case I know of the endpoint will be NA superiority to the AZ vaccine. By this standard we can be sure that Moderna low dose already meets this standard and of course going with a lower dose of an approved vaccine means that safety issues are off the table. This is the only pathway to immediately double capacity from Moderna and even if only part of their supply was allocated to this it could mean a few hundred million additional vaccines in 2021. Trevor Get Outlook for iOS From: Trevor Mundel HR 2 «21s foundation.org> To: Tony Fauci HEE 2 niaid.nin.gov> Cc: Christa Bowles HR 6 «21 esfoundation.org> Subject: Connect with Bill Date: Tue, 31 Mar 2020 22:02:12 -0400 Importance: Normal Hi Tony, great work in keeping things on such an even keel. Bill was keen to catch up with you and I wondered if you might have 30-45 min any time between 5:30pm and 8pm EST tomorrow to chat with him. Regards, Trevor Trevor Mundel, MD, PhD President, Global Health Program Vv' E E gatesfoundation.org Christa Bowles Executive Assistant Office of the President, Global Health Vv M E )gatesfoundation.org Bill & Melinda Gates Foundation www.gatesfoundation.org E]" 'les h Bill to Tony F but got an tomorrow || > 2 PM

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https://www.medrxiv.org/content/10.1101/2021.06.30.21259787v1.full.pdf Bill, Tony, this is the low (1/4) dose Moderna data which looks quite strong - I know Sette has a lot of additional data he presented over the weekend and I'm trying to get this from him. quoted / not their view quoted_external message body appears to be pasted content asserts
Regulatory authorities (EMA and MHRA thus far) have agreed to immunogenicity phase 3 trials for the new vaccines coming along due to the inability to do standard phase 3 - in the 2 case I know of the endpoint will be NA superiority to the AZ vaccine. quoted / not their view quoted_external message body appears to be pasted content acknowledges
By this standard we can be sure that Moderna low dose already meets this standard and of course going with a lower dose of an approved vaccine means that safety issues are off the table. quoted / not their view quoted_external message body appears to be pasted content asserts
This is the only pathway to immediately double capacity from Moderna and even if only part of their supply was allocated to this it could mean a few hundred million additional vaccines in 2021. quoted / not their view quoted_external message body appears to be pasted content asserts

In context

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  1. 2021-07-26 15:23 Trevor Mundel
    https://www.medrxiv.org/content/10.1101/2021.06.30.21259787v1.full.pdf Bill, Tony, this is the low (1/4) dose Moderna data which looks quite strong - I know Sette has a lot of additional data he presented over the weekend and I'm trying to get this from him. Regulatory authorities (EMA and MHRA thus far) have agreed to immunogenicity phase 3 trials for the new vaccines coming along due to the inability to do standard phase 3 - in the 2 case I know of the endpoint will be NA superiority to the AZ vaccine. By this standard we can be sure that Moderna low dose already meets this standard and of course going with a lower dose of an approved vaccine means that safety issues are off the table. This is the only pathway to immediately double capacity from Moderna and even if only part of their supply was allocated to this it could mean a few hundred million additional vaccines in 2021. Trevor Get Outlook for iOS From: Trevor Mundel HR 2 «21s foundation.org> To: Tony Fauci HEE 2 niaid.nin.gov> Cc: Christa Bowles HR 6 «21 esfoundation.org> Subject: Connect with Bill Date: Tue, 31 Mar 2020 22:02:12 -0400 Importance: Normal Hi Tony, great work in keeping things on such an even keel. Bill was keen to catch up with you and I wondered if you might have 30-45 min any time between 5:30pm and 8pm EST tomorrow to chat with him. Regards, Trevor Trevor Mundel, MD, PhD President, Global Health Program Vv' E E gatesfoundation.org Christa Bowles Executive Assistant Office of the President, Global Health Vv M E )gatesfoundation.org Bill & Melinda Gates Foundation www.gatesfoundation.org E]" 'les h Bill to Tony F but got an tomorrow || > 2 PM

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