Private channel session 674

5 messages over 1h 29m, 2020-12-14 – 2020-12-14.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

1. 2020-12-14 11:51 Edward C. Holmes open PDF p.313
   This does look like the sort of evolution I saw in cases of virus evolution in immunocompromised hosts. I've never quite understood why you see so much evolution in antigenic proteins in patients should not be mounting animmune response. Very striking in the noros.
2. 2020-12-14 12:31 Andrew Rambaut open PDF p.313
   Yes - noros is a good example. You have very long term shedders with basically no symptoms.
3. 2020-12-14 12:32 Andrew Rambaut open PDF p.313
   Perhaps it is the weakened immune response rather than an absent one which enhances selection by providing the chance for mutants to arise.
4. 2020-12-14 12:53 Kristian G. Andersen open PDF p.313
   Yup, I think "weak, not absent" may be key here.
5. 2020-12-14 13:20 Edward C. Holmes open PDF p.313
   Agreed.