Slack / Private Message Drop — page 387

Some helpful structural slides from Ian Wilson this morning - I think he'll share the whole deck. 417/484/501 - definitely looks like immune selection to me. [shared file(s): Screen Shot 2021-01-12 at 10.23.30.png, Screen Shot 2021-01-12 at 10.25.13.png, Screen Shot 2021-01-12 at 10.29.14.png, Screen Shot 2021-01-12 at 10.31.10.png, Screen Shot 2021-01-12 at 10.32.47.png, Screen Shot 2021-01-12 at 10.34.08.png] [2021-01-12 12:36:02] [Robert Garry] NIce slides - Nelly, Erik and I guess Karen (K417N). Yeah - they are all going to affect neutralization (slide 2) they question is by how much. BTW - dose 1 of Pfizer in my arm. [2021-01-12 13:03:20] [Kristian Andersen] Yeah, I saw those slides and there was no doubt in my mind. Very glad to hear you got the shot!!!!!! I'm worried about always seeing you in your office Bob :wink: [2021-01-12 13:06:11] [Robert Garry] https://news.cgtn.com/news/2021-01-11/CGTN-Exclusive-Interview-with-WHO-expert-to-China-on-COVID-19-origin s-WXVDUh1kL6/index.html Koopsman who is a rather strong personality will likely have a large impact on the WHO panel. That being said, it's hard to draw out much about her thinking here. This interview does not change my mind that this is going to be very superficial. NOT much is coming out the the WHO or Lancet origins panels. [2021-01-12 13:09:42] [Robert Garry] I [2021-01-12 13:10:31] [Robert Garry] You can bet I'll be using my plasma for some vaccine escape studies.... [2021-01-12 14:11:19] [Eddie Holmes] Yes, I saw that. Waste of time. About 3-4 weeks I emailed GG to see if could meet up with Dominic Dwyer - my mate from Sydney who is on the WHOO commission. TODAY he replies saying that he will try and find a time-slot. She also implied that they would be looking at the early European data which is ridiculous. [2021-01-12 14:17:49] [Eddie Holmes] Ok, some CONFIDENTIAL pango news: UHK have animals confiscated in 2013 and 2018 in Hong Kong. Direct from Malaysia we think. Of those 9 are seropositive (using the Wantai ELISA SARS-CoV-2 assay) and 5 are PCR positive using Hybribio SARS-CoV-2 RT-PCR kit, although 4 of these have high CT values. Enrichment, meta-transcriptomics and luciferase immunosorbent assays (to rule out cross-reaction) ongoing. At face value suggests that SARS-like CoVs have been in Malayan pangos for a while but this needs to be confirmed. I'll update when I have more news. Obviously keep to yourself. [2021-01-12 14:33:31] [Robert Garry] Thank you Eddie - very important! [2021-01-12 14:35:08] [Robert Garry] I think this is an important clue: [shared file(s): image.png] [2021-01-12 14:37:27] [Andrew Rambaut]