Slack / Private Message Drop — page 343

[2020-12-23 16:32:31] [Robert Garry] Thanks Eddie - appreciated much... [2020-12-23 16:39:58] [Robert Garry] Another point to throw out - "Baric or Fouchier making SC1 N493Q + T487Y is not my most serious concern. Perhaps even they would draw the line at that. However, nature is not so kind and I do believe that we need to act preemptively with additional CoV vaccines. IMO we need to follow-up the SC2 vaccine program with SC1 and MERS-CoV vaccines much sooner than later. [2020-12-24 06:44:33] [Robert Garry] https://www.nature.com/articles/s41576-018-0055-5 Great article from @Eddie Holmes - this is the figure that has me a bit concerned. [shared file(s): image.png] [2020-12-24 08:21:01] [Robert Garry] Knowing what we know about the NEJM patent who was treated with Regeneron would you treat an immunocompromised SC2 shedding patient with Regeneron? Asking for a friend. [2020-12-24 14:30:11] [Andrew Rambaut] Merry Christmas to the Idiot Pangoliars [2020-12-25 10:12:33] [Robert Garry] https://www.nature.com/articles/s41467-020-17367-2 Gentlemen - a third example of human SC2 adaptation to another species. "Two substitutions were detected in the consensus sequence of viruses collected from all ferrets as compared to the sequence of the original virus isolate: N501T and S686G, both in the spike protein." So WoW, the mink N501T plus the residue AFTER the FCS. More grist for PO2. [2020-12-25 10:17:11] [Robert Garry] There may be a ferret N501Y mutations somewhere - looking... [2020-12-26 09:44:50] [Robert Garry] https://www.cnn.com/2020/12/24/us/acfc-virologist-nathan-wolfe/index.html 2008 - something with Wolfe went terribly wrong right around this time... [2020-12-26 09:54:29] [Kristian Andersen] Heh... Alternative title - "Former celebrity scientists said what everybody knew was true in 2008". [2020-12-26 09:54:39] [Kristian Andersen] Speaking of scientists who lost the plot - https://www.youtube.com/watch?v=wC8ObD2W4Rk&feature=youtu.be [2020-12-26 14:49:23] [Eddie Holmes] I enjoyed this one though Kristian: [shared file(s): Screen Shot 2020-12-27 at 9.48.50 am.png] [2020-12-26 14:49:41] [Eddie Holmes]