Slack / Private Message Drop — page 319

[thread - ID: 2020-12-16 06:57:48] @Andrew Rambaut Is it too far away from the FCS to be related to that? I ask because the South African outbreak with 501Y has a mutation at 701 apparently. [2020-12-16 07:01:17] [Andrew Rambaut] [thread - ID: 2020-12-16 06:57:48] @Andrew Rambaut Although now looking, it seems the ancestral amino acid is A [2020-12-16 07:22:36] [Robert Garry] [thread - ID: 2020-12-16 06:57:48] @Andrew Rambaut Yeah the A in the ancestral threw me off a bit, but - that region between the FCS and the S2' cleavage site it generally thought to be clipped out - the S2' cleavage exposes what is likely the fusion peptide (there may be other FPs). There is some thought in some of the other CoVs that that clipped out peptide between the FCS and the S2' site might have some biological activity, but I haven't seen anything convincing. [2020-12-16 07:25:44] [Robert Garry] [thread - ID: 2020-12-16 06:57:48] @Andrew Rambaut Is 701 too far away to affect the FCS? Yeah probably... [2020-12-16 07:36:07] [Andrew Rambaut] [thread - ID: 2020-12-16 06:57:48] @Andrew Rambaut :+1: [2020-12-16 09:08:38] [Kristian Andersen] I wouldn't rule it out - straight from Boris Johnson's chronic infection to the infested sewers of London. [2020-12-16 09:13:09] [Robert Garry] Also the Kings Cross "artist" Billy - his whole DRASTIC operation could well be a false flag. Just sayin'. [2020-12-16 13:29:24] [Robert Garry] Not too helpful IMO: [shared file(s): image.png] [2020-12-16 13:31:22] [Kristian Andersen] Let me chime in - that's idiotic [2020-12-16 13:31:42] [Andrew Rambaut] Go for it. :popcorn: [2020-12-16 13:50:58] [Eddie Holmes] Oh me too! [2020-12-16 13:54:53] [Kristian Andersen]