Gates Package — page 841

Fig.3. Phenotypic improvement in in vitro editing studies with CD34+ cells from - thalassemia and SCD patients. Analyses were done with the samples described in Fig.2. A) Percentage of Reactive Oxygen Species (ROS)-positive cells within total erythroid cells (CD235a+) and denucleated erythroid cells (CD235a+/NucRed- cells) for Thal samples and in total erythroid cells for SCD samples. B) Fold increase in erythroid cell numbers between days 7 and 18 of ED. Statistical analyses of the data from the Thal samples were performed using two-way ANOVA.