Gates Package — page 1360

© TREAT BY accomplished in several ways: + Method 1: mRNA vaccine encoding antigens that induce immune responses targeting cells that are HIV-infected AND/ OR * Method 2: mRNA vaccine encoding antibodies optimized to result in secondary antiviral immune responses upon binding to virus PARTNERS: Therapeutic vaccination might be NXIR) Mes VACCINATION How can mRNA vaccines and/or BNAbs be engineered to induce effective antiviral immune responses? Injection of mRNA/ LNP vaccine encodi Launch one or both approaches off an MRNAMlipid nanoparticle Top - Fab region: Targeted to "Env" or another HIV antigen Bottom - Fc region: Optimized (upon insertion of selected mutations) to more Single-shot mRNA therapeutic cure for viral infections potently induce antiviral immune responses sy -- = 'Abbreviations: bNAbs, broadly neutralizing antibodies; ER, endoplasmic reticulum; Fab, "variable" region of antibodies that confers specific binding to antigens like HIV; Fc, "constant" region of antibodies that confers effector functions; GA, Golgi apparatus; LNP, lipid nanoparticle INCENTIVES: Regulatory measures/endpoints for induced antiviral immune responses, costing infrastructures (to be developed) EMORY UNIVERSITY G if Source: Modema Blog Not for distribution