Gates Package — page 1355

® PROGRAM IMMUNITY How and where are immune signals transduced & processed? Antigen Input Immune processing Cell activation Immune outcome earmim@) RNA stem joop ae pay * Increase a= anti-CD11B oten {on} - Dendritic Pp cy cell (DC) + Improve Know and control the location and INP ; durability duration of specific immune responses * Mucosal @ Protection Antigen *« Dose anti-MHC II Reduction Fit for purpose, directed interventions that lead to durable protection from severe disease Yale SCHOOL OF MEDICINE INCENTIVES: Regulatory guidance/clarity for approval processes on severe disease endpoints, costing infrastructures (to be developed) EMORY UNIVERSITY SCHOOL OF MEDICINE G if Not for distribution