Gates Package — page 1299

TBRU-N NIAID Tuberculosis Research Units Network "Conduct research to address pauci-bacillary stages of TB (latency and persistence) through integration of human studies and animal models" TBRU-ASTRa Emory University Tri-1 TBRU Weill Cornell Medical College Identification of human Mtbspecific T cell signatures that are associated with resolved and persistent Mtb infection ¢ Human genetics of reactivation . pulmonary TB ¢ Innate, transcriptomic, and microbiomic correlates of TB infection « HumanT cell responses ¢ Viable but non-culturable M. permissive for progression to tuberculosis active TB disease ¢ Biomarkers of Pyrazinamide activity and its target bacterial populations ¢ Mouse models for pauci-bacillary persistence ¢ CETR Supplement: Identify drugs and chemical probes targeted to inhibit bacterial persistence Macaque T cell signatures of Mtb control . Armauer Hansen Research Institute Addis Ababa, Ethiopia st i] GHESKIO Port-au-Prince, Haiti oe KEMRI/CDC Kisumu, Kenya TBRU- LIMAA Brigham and Women's Hospital Multi-disciplinary analysis of host metabolic determinants of the spectrum of TB clinical phenotypes Identification of host genetic determinants of immune response and TB control Discovery of diagnostic biomarkers for acute and recurrent M. tuberculosis disease in humans with parallel mechanistic studies in guinea pigs a < Socios en Salud lima Peary CLEAR-TB TBRU Boston Medical Center Biomarkers to stratify risk of progression from latent TB infection to disease Validation and application of a model of human TB -- like latency in rabbits Bacterial mechanisms and host pharmacokinetic factors that determine persistence in pauci-bacillary TB Nucleo de Doengas Infecciosas Vitoria, Brazil