Fauci Intelligence Community Release — page 75

UNCLASSIFIED UNCLASSIFIED i DARPA: Defense Advanced Research Projects Agency ii PREEMPT: Preventing Emerging Pathogenic Threats iv DRASTIC: Decentralized Radical Autonomous Search Team Investigating COVID19. This collection of scientists and sleuths broke open the lab leak hypothesis into the mainstream and has picked apart Chinese and World Health Organization (WHO) reports on SARS-CoV-2's origins in Wuhan. v DEFUSE: Defusing Threat of Bat-borne Coronavirus vi PREEMPT Volume 1 no ESS HR00118S0017 EcoHealth Alliance DEFUSE. Another description used: "We will develop recombinant chimera spike proteins from known SARSr-CoVs, and those characterized by DEFUSE, using details of SARS S protein structure and host cell binding, we will sequence, reconstruct, and characterize spike trimmers and RBDs of SARSr-CoVs, incorporate them into nanoparticles or raccoon poxvirus vectors for delivery to bats." vii Dr. James Gimbert, DARPA Program Manager states: "team's approach does potentially involve GoF/DURC research (they aim to synthesize spike glycoproteins that may bind to human cell receptors and insert them into SARSCoV backbones to assess capacity to cause SARS-like disease." viii "We will commercially synthesize SARSr-CoV S glycoprotein genes, designed for insertion into SHC014 or WIV16 molecular clone backbones (88% and 97% S protein identity to epidemic SARS-Urbani). These are BSL-3, not select agents or subject to P3CO" (they use bat SARSr-CoV backbones which are exempt)" ix Duke NUS Medical School, UNC, USGS National Wildlife Health Center, Palo Alto Rsesearch Center, Kumning, Signapore, and Madison, WI. x PREEMPT Volume 1 no ESS HR00118S0017 EcoHealth Alliance DEFUSE xi PREEMPT Volume 1 no ESS HR00118S0017 EcoHealth Alliance DEFUSE xii "For Delta, neutralizing antibodies have a decreased affinity for spike protein, while facilitating antibodies have a "strikingly increased" affinity for spike protein." Yahi, et al. "Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?" Journal of Infection. August 9, 2021. https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext For SHSGAC Use Only - SHSGAC_COVID_119th 011837