Tony's Diary Package — page 890

even talk to him about this since I know from my experience that if we do anything, he will say that we were trying to muzzle him. As far as I am concerned he could say whatever he wants to say, as crazy as it is, whatever he wants to say. Also he said that he is refusing to get vaccinated The problem with this is that the new rule from the federal government is that if he does not get vaccinated he is going to get fired unless he has a religious exemption. If it turns out that he winds up getting fired, he will almost certainly say that it is retaliation. PRESS: Hugh Hewitt radio interview; NPR Radio "Here and Now" with Tonya Mosley; MSNBC - "Reports" with Andrea Mitchell; KLZ Israeli Radio; Sept. 30, 2021 - Global - 233,100,000/4,800,000; USA - 43,300,000/694,700 Cases continue to gradually come down as do hospitalizations. Deaths, however, are still increasing as a late indicator and lagging. Just had a great conversation with Shane Crotty of the La Jolla Institute of Immunology. I spoke to Shane because I wanted to find out his perspective on the immunological justification for booster shots to the mRNA vaccines. Shane is a brilliant immunologist and gave me some terrific insights. He feels , similar to Bob Seder, that the antibody levels are very important in preventing initial entry of the virus and seeding of the virus in the upper respiratory tract. The higher levels of antibody the more protection you have. They also taper off reasonably quickly leading to rather quick (months) waning of immunity to infection. However, he points out that B cell memory and particularly CD8 and CD4 positive T cells are absolutely critical in preventing significant disease in the lungs. These are longer duration than serum antibody. This explains why protection against severe disease (lung involvement) seems to last long and wane less than protection against infection (antibody that wanes quickly). The thing he pointed out that is interesting and important is that there is a reasonably longer period of time for people to develop pulmonary involvement and severe disease since the T cells have enough time to protect the lung. When they fail then you get lung involvement and this usually takes some time which explains the unusual finding of why it takes so long from the time a person gets infected to the time they actually wind up in the hospital on a ventilator which is usually about 21 days. This is quite different from other acute viral infections in which the lung is quickly attacked and people wind up in the hospital within a couple of days. In addition, he spoke of the long durability of the T cell memory and B cell memory response indicating that protection against severe disease will actually last for a longer period of time whereas protection against infection tends to veer off pretty quickly. It is right in line with what his pathogenic explanation is as described above. He does feel that giving a third shot boost is a good idea and that it likely will give a much longer protection against both infection and likely would enhance the durability of the protection against severe disease in the lungs. We also discussed the situation of why in late disease you have an aberrant inflammatory and immunological response. He believes it's a combination of innate immunity mediated predominantly by monocytes and polys together with robust T cell