Diary Prequel Package — page 463

cherry-picked information for his own advantage. Following the interview, when I got back to my office, I received several e-mails telling me that I did a very nice job in being balanced in my approach. There has been an additional case of Ebola in Liberia. A 17-year-old boy was found dead and was shown by PCR to have had Ebola. Since then, there has been an additional case or two. Therefore, we are concerned that this may be the beginning of another outbreak in Liberia and perhaps in other West African countries. Drew Faust, President of Harvard had e-mailed me a couple of days ago to ask me for suggestions for Dean of Harvard School of Public Health to replace Julio Frenk who had left to become President of University of Miami. I gave her several names and then she responded this AM thanking me and telling me that she had just watched "Larry Kramer: In Love and Anger " (HB0) and this was her comment to me: I spent the evening tonight watching the Larry Kramer HBO documentary in which you figure so prominently--and impressively. The footage throughout is amazing, (I kept thinking what it would be like to have such a record of the Civil War...), and the story both tragic and triumphant. I was powerfully struck by your comment towards the end about how Act Up permanently changed everything in how officials, the state and organized medicine deal with patient communities. The film will remain in my mind for a long time... Very best, Drew July 7, 2015 - Met with team from Gilead Sciences who presented data on their new compound GS 5734 that has impressive preclinicakl activity against Ebola. They want our help in testing it in West Africa. It is an RNA Polymerase with activity against MERS, and likely RSV, Chik, and others. We will help them and do a trial in West Africa after we finish the ZMapp trial that is moving along well (47 subjects thus far) in Sierra Leone and soon in Guinea. Infections persist in both countries. Also, last week there was an infection in Liberia with 2 secondary cases. The Gilead people were: Andrew Chang (Head of HIV Therapeutics & Development Operations; William Lee (Head of research); Howard Jaffe (Senior Advisor); and Tomas Cihlar (Head of Discovery Virology). Also, Cliff is back from Guinea and it looks like (despite the continued objections of tom Frieden), we will expand the RCT Vaccine trial into Guinea where there are persistent cases. Had diner tonight at Grapeseed restaurant in Bethesda with the BMGF people who are in town for our yearly joint gates/NIH meeting. Francis Collins and I and Doug owy were the senior NIH people there and Trevor Mundel, Emilio Emini, Chris Carp, Chris Wilson were senior Gates people among others.