Diary Prequel Package — page 430

lical of snow and all flights were cancelled from Boston to DC. I would have been stuck there. March 6, 2015 - Met with Nina Russell and Emilio Emini from the Bill and Melinda Gates foundation (BMGF), Emilio is taking over as the Director of Global Health for BMGF and he wanted to review our mutual commitments for the AIDS vaccine plans (i.e. the P5 follow-up of the RV144 study). He wanted to re-examine the criteria for moving forward with candidates. Emilio generaly thinks that he knows everything; however, on this one he has a valid point and so we will do this together. Cliff Lane in Liberia (also Sierra Leone) now for the 7th time in a few months trying now to expand the RCT vaccine trial to Guinea and also expand the therapeutic trials with ZMapp to Sierra Leone and possibly Guinea since there are virtually no patients in Liberia. Cliff and I had phone call early (6:30 AM) with Cliff in Sierra Leone, me in DC at home, and Yves Levy and Jean-Francois Delfraissy in Paris to try and get a collaboration going in Guinea for the trials since the French have a presence in Guinea. March 9, 2015 - Went downtown today to be the BBC studio to do the final taping of the segment that they will be doing on HIV/AIDS were I am the moderator and narrator. In the afternoon, I attended the FDA/NIH Leadership Council meeting to discuss better ways of collaboration between the NIH and FDA. March 10, 2015 - Gave the after dinner talk at the Project Hope Board meeting at the Willard Hotel in Washington DC. I spoke on Ebola: The Perfect Storm. It was extremely well received and the evening was pleasant. Ran into former Secretary of HHS Louis Sullivan. March 11, 2015 - Was Visiting Professor at the John's Hopkins Hospital and Medical School. Gave two major talks: 1) a formal lecture on Ebola, and 2) a lecture to the students and fellows on my career as a scientist, clinician, policymaker. March 12, 2015 - There was a considerable misunderstanding involving a situation in Sierra Leone. Cliff Lane is trying to expand the randomized controlled trial of ZMapp versus standard of care in countries in addition to Liberia with the protocol he has already started. As it turns out the commanding general in charge of the British military hospital in Sierra Leone, Brig. Gen. Tim Hodgetts, was under the misimpression regarding the protocol was standard of care to see ZMapp + standard of care versus standard of care alone . And so he said that this trial was unethical and refused to participate in it. The reason why this is important is because an American citizen who works for Partners in Health became infected while working in Sierra Leone. We had made arrangements to air evacuate the patient to the NIH clinical Center as soon as possible. Because the patient was in the British facility, we wanted to start the randomization to one or the other arm of the protocol while the patient was still in Sierra Leone before flying back the United States. Brigadier General Hodgetts stated that he would give ZMapp as a compassionate use but would not participate in the randomized protocol. He felt it was unethical to delay the flight to the USA by giving the person a placebo if in fact the person randomized to