Diary Prequel Package — page 410

remote areas without good reporting. Also, the issue of second waves in Guinea and Sierra Leone. CDC having to put much effort into investigating Person Under Investigation (PUIs). These are people who are from West Africa who get a fever or nausea or vomiting for any of a number of benign reasons. Since they are from West Africa, these are being investigated, sometimes using PPEs, which is an "abundance of caution", but a major investment (?waste) of effort. Cliff Lane is in Monrovia doing spade work for the hopefully upcoming RCT for the Ebola vaccine. Heard on Secretary's call this AM (8:30 AM on Saturday) that now WHO (likely MariePaule Kieny) wants WHO to be responsible for the DSMBs of all clinical trials in West Africa. This is an egregious attempt on the part of WHO to stay "relevant" in an area in which they have no expertise. It is "stunning" to me how they just want to insert themselves into things where they quite frankly are incompetent. They already have made it clear that they just want to distribute unproven interventions (vaccines and treatments) and even though we seem to be winning the argument, they keep coming back in insidious ways to try to derail the scientific clinical trials process. Amazing!! Nov. 2, 2014 - Quiet Sunday. Trying to catch up on piles on my desk. Election on Tuesday. Concern that the GOP will take the Senate, which means Obama is in trouble with both House and Senate in GOP control. Despite reports that the number of cases in Liberia are decreasing rapidly, new reports today indicate that the cases in Sierra Leone are sharply increasing. I have warned that Ebola comes in waves and that we should not be complacent and the WH should refrain from saying that things are "turning around". Nov. 3, 2014 - Ron Klain visited NIH today (He had visited CDC last week). He wanted to familiarize himself with what the various components of government were doing in Ebola. I made a presentation to him in the VRC, showed him the lab where Nancy Sullivan works and where she developed the ChAd3 Ebola vaccine. Then we took him over to the Clinical Center to see Julie Ledgerwood's vaccine clinic where the phase 1 trial took place. Then we showed him the SCSU and the room where we took care of Ron was impressed and wants me to come to the WH on Friday to give a shortened version of my presentation at a meeting where the POTUS is hosting certain Congressional leaders. Tom Frieden spontaneously called me up to thank me for being so supportive of him. I have been continually serving as a late night (by phone or e-mail) sounding board for him in his attempts to negotiate his having to deal with some many factions (ASPR, HHS, USAID, etc.) Last night I helped him out by strongly suggesting that he not listen to the modelers who tell him "exactly" how many news cases of Ebola to expect in the USA over a period of time. I warned him that the models are based on assumptions and multiple variables and can be very misleading and he should not "own" data that comes