Diary Prequel Package — page 357

geria following the will propose this at the next Secretary's call. The logistics of this will be difficult due to the lack of infrastructure in the 4 African countries. Did WBAI Radio in NYC and Al Jazeera TV today. Latest numbers for Ebola - 1900+ cases and 1050 deaths August 14, 2014 - Things quieting down a bit in the press. Still struggling with ethics issues and clinical trials issues. Canada has "hot-dogged" by announcing that they are "donating" 400-800 doses of their vaccine for use in Africa. Of course, that is exactly where we will give it when we show that it is safe. Also Jeremy Farrar, the head of Welcome Trust is grandstanding a bit saying we must not just "sponge down the patients and let them die". Give me a break. Now WHO wants to use the Phase 1 doses of vaccine to vaccinate their people who are going to Africa. They want 200 doses to do a "phase 1 trial" in their staff. 200 doses is a product distribution program, not a phase 1 trial. Did CBS News and AP TV today. August 15, 2014 - Went up to Philadelphia to see the White Coat Ceremony at the University of Pennsylvania Medical School where my daughter Megan is beginning her first year of medical school. Beautiful day and wonderful ceremony. We are so proud of Megan and hope that she will be happy. I know that she will do well having graduated summa cum laude from Columbia and then excelling in the Post-Bacc pre-med year at Hopkins. August 16-19, 2014 - Media blitz stopped, but the epidemic still rages. The West African countries are instituting quarantines and border closings, which may slow down the epidemic, but there is the beginning of a humanitarian crisis to get food, water and supplies to the quarantined areas. Tom Frieden and I are working out how we can reconcile the issue discussed above about the balance of open access of vaccine following phase 1 versus the need to know by RCT whether the vaccine actually works and whether it might actually do harm, as per the Ad5 HIV vaccine enhancement of HIV acquisition in a former clinical trial a couple of years ago. The department was clearly concerned (Andrea Palm - chief-of-staff to Burwell- pissed me off on a conference call by acting annoyed with Tom and me in our discussions on the daily conference call) about the disagreement between Tom and me; however, Tom and I are now trying hard to work it out behind the scenes. August 20, 2014 - Ebola still on an upswing. No explosion yet in Nigeria following the infection of cluster (8 to 11) health care workers who took care of (Liberian/American) who flew from Liberia to Nigeria). Tom Frieden and I still trying to work out an agreement/compromise regarding the distribution of Ebola vaccine (RCT versus expanded access) following the Pahe 1 trials that will begin in September and have data by November on Safety and immunogenicity.