Diary Prequel Package — page 160

White Paper that we (NIAID) had contributed to a couple of months ago when we introduced our Research Agenda for MDR/XDR-TB. Beautiful Fall day (crisp and sunny). Meeting from 9:00 to 11:00 AM followed by briefing from Tachi Yamada (Gates Foundation) who came from Seattle to present to us (USG) out of courtesy the new $282 million Gates TB initiative. In preparation for this I alerted Rajeev that we really needed to coordinate the many USG activities on TB and present it in a vision format so that the POTUS could claim the legacy of having addressed AIDS (PEPFAR), malaria (President's Malaria Initiative - PMI) and now TB. It would be the 3rd leg in the stool of his Global Diplomacy program. Rajeev agreed - unfortunately, he will be leaving government on Sept. 26. It was great working with him over the past few years. His background is that he trained as an MD at Michigan and was actually Chief Medical Resident when Tachi was Chairman of Medicine at Michigan. In any event, we will update and sharpen our USG White Paper. Sept. 20, 2007 - Another great crisp Fall day. Heard real bad news regarding the Merck AIDS vaccine trial 502 in which adenovector HIV was immunogen. Study done mostly on gay men and phase 2b was looked at by DSMB on usual periodic look. Trial closed for "futility" in that the data showed that more people got infected in vaccinate group versus unvaccinated group (19 vs 11 - not significant, but highly suggestive). Also, viral set point exactly same in infected people who were vaccinated versus those that were not. Trail stopped - press releases imminent. It is going to be a hot time. People will focus on whether we should proceed with the Phase IIb of PAVE 100 (Gary Nabel's VRC trial). The latter also was a adeno vector, but is different in 3 ways: 1) it has a DNA prime; 2) it has envelope; 3) it is done also in heterosexuals. More to come. Went to Gate-sponsored dinner at Le Paradou Restaurant at 678 Indiana Avenue, NW in honor of retiring President of Botswana Festus Mogae. I had met the President in 2002 when I went to Africa with Tommy Thompson in 2002 to develop PEPFAR. At the dinner were: Todd Summer and Cheryl Scott (Gates), Jeff Struchio (Merck), Bobby Pittman (NSC Director of African Affairs), Congresswoman Nita Lowey, Tommy Thompson, Max Essex (Harvard School of Public Health), Ambassador John Lange (former Amb to Botswana), Jendayi Frazer, Assistant Secretary of State for African Affairs. Nice evening. I commiserated with TGT about his failed attempt at Republican nomination for President. Nice conversations with Nita Lowey about Iraq (Democrat viewpoint), and warm conversation with Mogae regarding my work on AIDS. Sept. 25, 2007 - Was panelist at Science Magazine's annual retreat of their staff at their headquarters in Washington, DC. Chaired by Editor Don Kennedy. Lively discussion about the future of science and biomedical research. DSMB discontinues trial of Merck HIV vaccine based on Adenovirus vector. Possible that vaccine actually made things worse. Big setback for HIV vaccinology. Sept. 26, 2007 - Farewell reception at White House for Rajeev Venkayya (Deputy Director - Homeland security Council). I have worked closely with Rajeev for 5 years on Biodefense. He rose from WH intern to deputy Director in 5 years. He is someone to