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A % Inhibition pare non ot aag PFU/mL Log Fold ChangefMock EIDD-1931 % Inhibition MERS-CoV in 2B4 Cells , ied nN a 0.001 0.01 EIDD-1934 [uM] MERS-CoV: Virus production and viral RNA production in HAE 10° = 10' I $0 $e gm © ao 10° 4 ° & 10° - 10°. * I @ MERS-CoV Titer bd - com lod PES r ie 0 -mo - ag BO a hd . © no I -24 8 _ eicintemncens @ Subgenomic R . CES OS Ergo % oS MSP % HOPS MS EIDD-1931 (M] -25 AYOIXOL % B Cell death factor expression in HAE IDD- [UM] St sporine 0.37| I W 0.42/ I 0.047| 100) $3 441_ M25 --t Hddyo/a5ueyo pos auro- Fh OPE BPRS SE i g a: D SARS-CoV: Virus production and viral RNA production in HAE "1 10°54 ' 10) oa oS Eiji" ® és 2 & 10°) @ SARS-CoV Titer ve 2 10+ lod 10° I ee x ° . Oat at Be et ge 90 aa BS g. § -24 a Ba rs) a a be . & 3-4] @ Genomic RNA(ORF1) '> 8 Subgenomic RNA (ORFN) clei Se Eee TTS oss St e ea EIDD-1934 [yM]