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5/14 Conserved Sites 2019-nHCovV S Glycoprotein RBD Interface R WUCV S-RBD ACE2 Interface Residues* SARS-CoV CUHK-W1 GDO03 HC/SZ/61/03 I un fo be <\<j\<I\< re. WIV16 I Rs3367-- wiv1 SHCO14 PDF2386 zj]2\I~ |x |2\2 |x jaa <I<I<I<I<I</</< n of2\i2zizi2zizizizi2 ZXC45 ZXC21 IWUH Original = < «<d<I< I <I<I</<I<I< ~< nm I< I<I<I</I<j|</< OID |D|DAA Aaa IWUH 402121 Rp3 HKU3 Rm1 Rf << I< I< I< I< p<j<f< I< I<]< I< I<I<I</</</< alalalaiasahaia fa la saga la lalal/aiaiaia Y 14 Contact Interface Residues that interact with ACE2 Recepto *Conservations based on BLOSUM62 Matrix ululululelalo lo lulu |xi>|2\2}2|/2 |2zjz)2 j2l2|ujul2 whalafa l2 |aga ia |alaiaiaiaia < <f2\2]<I<I<j>i2\2\/2\4 < Variation across the contact interface residues can alter orthologue AC Change Intermediate Host?