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Common Features Pre-epidemic Group 2B SARS-like C Origins: BATS Use hACE2 Receptor for docking and entry -- Use other ACE2 receptor orthologues for entry into species Grow efficiently in primary human airway epit cells, and small airway epithelial cells Cause Acute Respiratory Disease Syndrome (A humans and/or Animals -- End stage lung disease with ~30% mortality rates Cause an Age-Related Disease Phenotype -- Characterized by Increased Virus Growth and Morta immune senescent populations