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© BLOCK TRANSMISSION Reducing transmission Reducing infection Transmission blockers applied How do we protect the nose and upper to the nose and upper airways airways from pathogens, so they are unable to infect and spread? Aeoues in 3 virus € alrways " neutralize the For'example: virus on entry + Innate immune activators New platforms for potent, durable, and * mRNA low-cost approaches that can be applied a encoded at scale to prevent pathogen 4=K biologics transmission + RNAI iM I + Low-cost durable , woe , antibodies Blocking transmission of respiratory or enteric pathogens PARTNERS: @ LUMEN & eleven INCENTIVES: Regulatory measures/endpoints for approval of BIOSCIENCE THERAPEUTICS @ EMORY transmission-reducing interventions, payment codes/infrastructure for Tether I Yale scHOOL OF MEDICINE Unitas transmission reduction, price/ volume guarantees (to be developed) Therapeutics MEDICINE Gf Not for distribution 16