Attachment
Gates Package, p.1354 · gates:exh:00633
Page text: p.1354 · original PDF
- Date
- — (unknown precision)
- Type
- attachment · document
- Topics
- Vaccines
®
MANIPULATE CELL STATE AND FATE
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CAN WE APPLY RATIONAL CONTROLS TO IMMUNE
AND STEM
CELLS?
KEY QUESTION(S)
al
What non-genetic perturbations
influence cell state and fate?
Waddington's epigenetic landscape
Rational controls in biological systems
Stem cells
/mmune cells
_
FUTURE STATE
LNP -->
a4
f
-
Ea
I
W Identify models and frameworks to
=
i
define biological controls of immunity
Antigen input
'
and stem cell differentiation
Cell state
outputs
POSSIBLE APPLICATION(S)
ai
4 Programmable design of nextgeneration vaccines and therapeutics to
control specific immune responses
Cell differentiation
What controls can be used to
©)
define these varied outputs?
WHAT PARTNERS/INCENTIVES COULD ENABLE THIS WORK?
INCENTIVES: (to be developed)
PARTNERS:
Gf
Not for distribution