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© SMELL THE VOLATILOME WITH BIOSENSORS @) HOW DOES CHEMO-SENSING WORK? Olfactory receptor signaling Olfactory Neurons Offactory neuron I Odorants Electrical activity in olfactory bulb Abbreviations: ACIII, type 3 adenylyl cyclase; OR offactory receptor; ORx, variable subunit; ORco, olfactory receptor subunit © WHAT PARTNERS/INCENTIVES COULD ENABLE THIS WORK? SCHRODINGER Caltech PARTNERS: (_YNANOPORE Duke canaery Gf Vv KEY QUESTION(S) Can we redesign and retune olfactory receptors to detect volatiles of human interest and importance? FUTURE STATE -- I Develop olfactory receptor (OR)-based biosensors to detect volatile or soluble chemicals POSSIBLE APPLICATION(S) Chip technology to detect odors that are signatures of disease/ health of humans, animals, and plants Tl INCENTIVES: Regulatory approval pathways for multiplexed biosensing of volatiles for disease signatures, creation of large public-private human volatile biomarker datasets, orphan drug status equivalency for pandemic preparedness targets, additional costing structures (to be developed) Not for distribution