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@) Preliminary TREAT BY VACCINE WHAT POTENTIAL RELATIONSHIPS COULD ACCELERATE THIS WORK? WHAT DOES IT MEAN TO TREAT BY VACCINE? Therapeutic vaccination might Top -- be accomplished in several Fab region: ft ie = Targeted to "Env" ways: first, by providing an Bs as Heay Chain) or another HIV mRNA vaccine that induces -- oats ci antigen immune responses targeting "Se a Light Bottom - cells that are infected; and vee ran Fe region: secondly, by Ab heavy chain d = @ Optimized to Per , Zp light chain- mRNA activate and providing engineered broadly ys ----.. .¢ enhance the neutralizing antibody "Encoded I immune response (bNAbs) that would, upon << Nine ies to viral infection Bydinore contact with the virus, result in Cytosol secondary induction of an Lily isat ry Example therapeutic vaccine method companies antiviral immune response. KEY QUESTION(S) POSSIBLE APPLICATION(S) Single-shot mRNA therapeutic cure for viral infections Gf Source: Moderna Blog. Not for distribution\ 8 How can mRNA vaccines and/or bNAbs be engineered to induce effective antiviral immune responses? Launch one or both approaches off an mRNA/lipid nanoparticle