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©) Preliminary BLOCK TRANSMISSION WHAT IS TRANSMISSION BLOCKING? Transmission blockers of the Reducing transmission nose.and upper airways Antibody mask: Antibodies (e.g., slgAs) bind to the virus in the airways and lungs, reducing exhaled viral loads. Reducing infection Antibodies in the airways and lungs neutralize the virus on entry and prevent I spread throughout the body. Understand how to block infection at the epithelium (e.g., Gl tract) How do we induce protective responses at sights of pathogen entry? WHAT POTENTIAL RELATIONSHIPS COULD ACCELERATE THIS WORK? BIOSCIENCE eleven Tether Therapeutics HERAPEUTICS Yale SCHOOL OF MEDICINE & EMORY UNIVERSITY SCHOOL OF MEDICINE And more, including new companies POSSIBLE APPLICATION(S) = Mucosal vaccine or antibody inhaler to prevent transmission Not for distribution 4