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@) Preliminary PREDICT AND DESIGN DE NOVO ODORS Neural network Molecule to graph operation [> Neural network for prediction I Fe 138 odor descriptions Molecule (eg, varilin) citrus creamy I sweet baked -- spicy HOW ARE BEHAVIOR-MODIFYING ODORANTS IDENTIFIED? Learned odor space* Scent prediction Novel molecule discevery for behavior modification (e-g. insect repellant Novel scent odorless varia neue) lean alcoholic beefy network checolate fruity layers Graph embeddings Graph bX) > to vector operation LE Tn TJ -- Can we redesign and retune olfactory receptors to detect volatiles of human interest and importance? A "This graph only shows two of the most important dimensions in the odor space. In realty, the odor space is > 100 dimensions. Identify new behavior-modifying chemicals and odors WHAT POTENTIAL RELATIONSHIPS COULD ACCELERATE THIS WORK? TROPIG SCJohnson HEA as SCIENCES USDA -- And more, including new companies POSSIBLE APPLICATION(S) New classes of mosquito repellants/ Cc) attractants that protect humans/ animals from vector born infections Not for distribution\ 1