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Gates Package, p.1099 · gates:exh:00509
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7, you
together to reduce the chances that a drug-resistant variant will emerge. (This
is done now with HIV treatments: Three antivirals are combined, limiting the
spread of resistant viruses.) These libraries need to be accessible to all
researchers so they can use different approaches to find out what should be
added to the library.
Use artificial intelligence and other software to develop antivirals and antibodies
faster. Several companies are doing great work in this field. Essentially, you
would build a 3D model of the pathogen that you want to target--it could even
be one we've never seen before--and also models of various drugs that you
think might work against it. The computer would quickly run these models
against each other and then tell you which drugs look promising. It can figure
out how to improve drugs or even design them from scratch.
Speed up clinical trials. A few efforts, such as the RECOVERY trial in the U.K.,
set up ready-to-go protocols and built up infrastructure that made it much
easier to get started once COVID hit. We should build on those models,
improving the ability to do trials around the world so we can learn what works
even when a new disease is present in just a few countries. Regulators need to
agree in advance on how people will be enrolled and on the software tools that
will enable enrollment globally, as soon as the disease strikes. And by
connecting diagnostic reports into the trial system, we can automatically
suggest to doctors that their patients should join a large-scale trial.
Diagnostics