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14 Part of its mission is to help poor COVID vaccine trials took place in Africa, the ones that did relied on South Africa's strong clinical trial infrastructure, which had been built with funding for HIV. The first evidence about how effective COVID vaccines would be against a COVID variant came from trials in South Africa. Buying and delivering vaccines Years ago, someone started a meme claiming that if I walked past a $100 bill lying on the sidewalk, it wouldn't be worth my time to pick it up. Although I've never had the opportunity to test this theory, I'm sure it's not true. I would absolutely pick up a $100 bill! First, I'd look around to see if I could find the person who dropped it, because someone is probably sad about losing their $100. And if I didn't see anyone, I'd take that money and send it where it could do the most good: Gavi, the Vaccine Alliance. Gavi has a phenomenal impact. It finances and organizes vaccines systems for children in low- and middle-income countries and has helped vaccinate more than 880 million children and prevented 15 million deaths in the past two decades.14 Part of its mission is to help poor countries buy vaccines, but it does much more than that. Gavi helps countries gather data to measure the effectiveness of their work and make improvements. It helps them build supply chains so that vaccines, syringes, and all the other necessary pieces reach the clinics where they're needed. It offers training for leaders in the health sector so they can manage their countries' vaccine programs more effectively and increase the public's demand for vaccines. The Gates Foundation helped create Gavi in 2001, with the goal of making vaccines available to all the world's children. We did not foresee the role that Gavi would play in