Attachment

G-CSF/AMD3100 " FA Ge 1 day2 day12_-- day 26 week 16-P g --. C57BV6 g D46tg/B-YAC tT ft t t + week 16S HDAG-EF10.ABE8e O®BG (30) O®BG (30) O®BG (30) Lincells --> () BCNU (5) BCNU (10) BCNU (10) secondary FeepINIS nays B $ Cc D E e ASG @ = A8>G (-113A>G) 100: © AGG -- 80-I ° All>G «© . 80: z ge z 8 40 8 40 x ze & balm 20. 20: ] ges srs soge reads F G _ Biele sequence mmm A>C CCAGCCTTGCCTTGACCAATAGCCTTGACAAGGCAAACTT 31.8 == A>G CCAGCCTTGCCTTGGCCGGTGECCTTGACAAGGCAAACTT me AT CCAGCCTIGCCTTGECCGATGGCCTTGACAAGGCAAACTT CCAGCCTTGCCTTGECCGATAGCCTTGACAAGGCAAACTT CCAGCCTIGCCTTGACCGATAGCCTTGACAAGGCAAACTT 1.37 CCAGCCTIGCCTIGGCCGGTAGCCTIGACAAGGCAAACTT 0.99 st CCAGCCTIGCCTTGGCCAATGGCCTTGACAAGGCAAACTT. 0.72 t CCAGCCTTGCCTTGACCGATGGCCTIGACAAGGCAAACTT 0.50 CCAGCCTTGCCTTGGCCAATAGCCTIGACAAGGCAAACTT 0.48 eg CCAGCCTIGCCTTGGCAGGTGGCCTIGACAAGGCAAACTT 0.47 3g CCAGCCTIGCCTTGGCAGATGGCCTIGACAAGGCAAACTT 0.46 CCAGCCTIGCCTIGGCTGATGGCCTTGACAAGGCAAACTT. 0.41 CCAGCCTIGCCTTGGTCGETGGCCTIGACAAGGCAAACTT. 0.41 0.001 ccasecTreccTTeacc: GACAAGGCAAACTT 0.26 AS AB AD AIT CCAGCCTIGCCTTGACCAATAG-----ACAAGGCAAACTT 0.20 ccacccrreccrre-------~ CCTTGACAAGGCAAACTT 0.19 H I Single colony, HBG1 Single colony, HBG2 = <= nonedited - == nomalelc z a oe = ine 3. s 0 © sa L&o _ os ve Fig.7 KS PBMC Bone marrow MNCs